Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993944 | 0.81 | — | — | |
| SCHEMBL4796162 | 0.81 | TEAD4 (0.59) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5131452 | 0.81 | KMT2A (0.50) | LTA4HALDH1A1MEN1KMT2ACA1 | |
| SCHEMBL755812 | 0.81 | MEN1 (0.46) | LTA4HALDH1A1MEN1KMT2AACHE | |
| SCHEMBL11411731 | 0.81 | LTA4H (0.50) | LTA4HALDH1A1MEN1KMT2ACA1 | |
| SCHEMBL5650797 | 0.81 | LTA4H (0.59) | LTA4HALDH1A1MEN1KMT2ACA1 | |
| SCHEMBL4796155 | 0.81 | TEAD4 (0.34) | LTA4HALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL754535 | 0.80 | LTA4H (0.55) | LTA4HALDH1A1HTTHAO1L3MBTL1 | |
| SCHEMBL20176875 | 0.78 | LTA4H (0.39) | LTA4HHTTSMN1; SMN2TDP1LMNA | |
| SCHEMBL14037485 | 0.78 | DYRK1A (0.53) | ALDH1A1MEN1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756104-B1 | TETRAHYDRONAPHTHYRIDINE DERIVATIVES USEFUL AS HISTAMINE H3 RECEPTOR LIGANDS | PFIZER LTD (GB) | 2010-12-15 | — | — | EP | disclosed |