Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.59 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005454 | 0.99 | ERN1 (0.60) | ERN1SMYD2MEN1KMT2AMAP4K4 | |
| SCHEMBL13005466 | 0.93 | SMYD2 (0.63) | ERN1SMYD2MEN1KMT2APARP1 | |
| SCHEMBL13005469 | 0.92 | CHRM3 (0.54) | ERN1SMYD2PARP1 | |
| SCHEMBL13060642 | 0.87 | ERN1 (0.62) | ERN1SMYD2MEN1KMT2AMAP4K4 | |
| SCHEMBL13061007 | 0.86 | ERN1 (0.64) | ERN1SMYD2MEN1KMT2AMAP4K4 | |
| SCHEMBL774938 | 0.82 | ERN1 (0.70) | ERN1SMYD2MEN1KMT2AMAP4K4 | |
| SCHEMBL13005547 | 0.81 | TACR2 (0.42) | ERN1SMYD2 | |
| SCHEMBL13060850 | 0.80 | SMYD2 (0.67) | ERN1SMYD2MEN1KMT2APARP1 | |
| SCHEMBL12334148 | 0.80 | NPSR1 (0.58) | ERN1SMYD2MEN1KMT2ANPSR1 | |
| SCHEMBL8252160 | 0.80 | NPSR1 (0.65) | MEN1KMT2ANPSR1CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |