Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | CTSL | P07711 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13060859 | 0.92 | BRD4 (0.36) | BRD4CTSLCTSSCTSKMETAP2 | |
| SCHEMBL13005538 | 0.84 | CTSS (0.42) | BRD4CTSLCTSSCTSKPSEN1 | |
| SCHEMBL13005525 | 0.84 | CTSS (0.42) | BRD4CTSLCTSSCTSKPSEN1 | |
| SCHEMBL13005486 | 0.82 | F2 (0.39) | BRD4CTSLCTSSPSEN1PSEN2 | |
| SCHEMBL13005623 | 0.79 | BRD4 (0.39) | BRD4CTSLCTSSCTSKMEN1 | |
| SCHEMBL13060805 | 0.76 | CTSS (0.44) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL13060644 | 0.76 | CTSS (0.44) | CTSLCTSSCTSKPSEN1PSEN2 | |
| SCHEMBL13005444 | 0.74 | KCNA5 (0.51) | BRD4KCNA5LMNA | |
| SCHEMBL13005534 | 0.73 | ROCK2 (0.40) | CTSLCTSSCTSK | |
| SCHEMBL13005536 | 0.73 | ROCK2 (0.40) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |