Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.56 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005440 | 0.88 | CALM1 (0.59) | BCHECALM1CAMKK2HTR2AMEN1 | |
| SCHEMBL13061028 | 0.85 | CYP1A2 (0.57) | BCHECALM1CAMKK2HTR2AHTR2C | |
| SCHEMBL10039139 | 0.84 | CALM1 (0.62) | BCHECALM1CAMKK2HDAC3HDAC1 | |
| SCHEMBL13005601 | 0.84 | CYP2D6 (0.46) | BCHECALM1CAMKK2HTR2ASIGMAR1 | |
| SCHEMBL13005625 | 0.83 | BCHE (0.47) | BCHECALM1CAMKK2MEN1KMT2A | |
| SCHEMBL13005681 | 0.83 | CALM1 (0.48) | BCHECALM1CAMKK2PYCR1MEN1 | |
| SCHEMBL13005722 | 0.83 | CALM1 (0.48) | BCHECALM1CAMKK2PYCR1MEN1 | |
| SCHEMBL13005707 | 0.82 | CALM1 (0.61) | BCHECALM1CAMKK2MEN1KMT2A | |
| SCHEMBL13005718 | 0.82 | CALM1 (0.71) | BCHECALM1CAMKK2MEN1KMT2A | |
| SCHEMBL13005546 | 0.82 | CALM1 (0.47) | BCHECALM1CAMKK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |