Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.78 |
| ▸ | JAK2 | O60674 | 2/20 | 0.68 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10215004 | 1.00 | MET (0.78) | METJAK2ALK | |
| SCHEMBL14647708 | 0.91 | MET (0.66) | METJAK2ALK | |
| SCHEMBL5252262 | 0.90 | MET (0.78) | METJAK2ALK | |
| SCHEMBL30452833 | 0.89 | MET (0.78) | METJAK2ALK | |
| SCHEMBL488558 | 0.89 | MET (0.78) | METJAK2ALK | |
| SCHEMBL16241930 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL13006019 | 0.88 | MET (0.75) | METJAK2ALK | |
| SCHEMBL488503 | 0.88 | MET (0.75) | METJAK2ALK | |
| SCHEMBL1823429 | 0.88 | MET (1.00) | METJAK2ALK | |
| SCHEMBL30753168 | 0.88 | MET (1.00) | METJAK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784396-B1 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-12-22 | — | — | EP | disclosed |
| EP-1786785-B1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-04-07 | — | — | EP | disclosed |