Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13005546 | 0.87 | CALM1 (0.47) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005713 | 0.86 | CALM1 (0.46) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13061136 | 0.86 | CALM1 (0.48) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005440 | 0.85 | CALM1 (0.59) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005676 | 0.85 | CALM1 (0.45) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005661 | 0.85 | CALM1 (0.45) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005601 | 0.84 | CYP2D6 (0.46) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005498 | 0.83 | CALM1 (0.46) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005561 | 0.83 | CALM1 (0.52) | CALM1CAMKK2TSHRALDH1A1KDM4E | |
| SCHEMBL13005715 | 0.82 | CALM1 (0.43) | CALM1CAMKK2TSHRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |