Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264825 | 0.89 | MEN1 (0.31) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL2264821 | 0.89 | MEN1 (0.31) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL342693 | 0.86 | AAK1 (0.33) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL357909 | 0.86 | AAK1 (0.33) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL342692 | 0.86 | AAK1 (0.33) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL18419552 | 0.84 | — | — | |
| SCHEMBL31191282 | 0.78 | AAK1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL28941238 | 0.76 | MEN1 (0.34) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL11106058 | 0.76 | MEN1 (0.34) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL29463474 | 0.76 | MEN1 (0.34) | MEN1GAAKMT2AHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130012564-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8283372-B2 | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2012-10-09 | — | — | US | disclosed |
| US-20120115922-A1 | SMAC MIMETEC | MEDIVIR AB (SE) | 2012-05-10 | — | — | US | disclosed |
| US-20110003877-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-01-06 | — | — | US | disclosed |
| US-20100317593-A1 | 2,3-DIHYDRO-1H-INDENE COMPOUNDS | ASTRAZENECA AB (SE) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012564-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | MEN1 1204/4885GAA 1291/4885KMT2A 2665/4885 |
| US-20110003877-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | MEN1 1204/4885GAA 1291/4885KMT2A 2665/4885 |
| US-20100317593-A1 | 2,3-DIHYDRO-1H-INDENE COMPOUNDS | BIRC2, BIRC5, BIRC8 | MEN1 2188/4885GAA 1788/4885KMT2A 3947/4885 |
| US-20120115922-A1 | SMAC MIMETEC | SMARCC1, SMARCC2, SMARCE1 | MEN1 296/4885GAA 741/4885KMT2A 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.