Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264821 | 1.00 | MEN1 (0.31) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL13006285 | 0.89 | MEN1 (0.31) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL342693 | 0.86 | AAK1 (0.33) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL342692 | 0.86 | AAK1 (0.33) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL357909 | 0.86 | AAK1 (0.33) | MEN1GAAKMT2AHDAC1HDAC2 | |
| SCHEMBL18419552 | 0.84 | — | — | |
| SCHEMBL31036506 | 0.78 | AAK1 (0.40) | MEN1GAAKMT2A | |
| SCHEMBL30414719 | 0.78 | FAAH (0.31) | — | |
| SCHEMBL30414771 | 0.78 | FAAH (0.31) | — | |
| SCHEMBL30414734 | 0.78 | FAAH (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2819996-B1 | 6-ALKYNYL PYRIDINES AS SMAC MIMETICS | BOEHRINGER INGELHEIM INT (DE) | 2017-01-04 | — | — | EP | disclosed |
| EP-2819996-A1 | 6 - ALKYNYL PYRIDINES AS SMAC MIMETICS | Boehringer Ingelheim International GmbH (DE) | 2015-01-07 | — | — | EP | disclosed |
| US-8859541-B2 | 6-alkynylpyridines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| WO-2013127729-A1 | 6 - ALKYNYL PYRIDINES AS SMAC MIMETICS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-09-06 | — | — | WO | disclosed |
| US-20130225567-A1 | 5-Alkynyl Pyridine | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-29 | — | — | US | disclosed |
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225567-A1 | 5-Alkynyl Pyridine | MKI67, API5, SMARCC1 | MEN1 1394/4885GAA 609/4885KMT2A 2164/4885 |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | MEN1 863/4885GAA 1977/4885KMT2A 3756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.