Sugi Predict

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SCHEMBL357909

SCHEMBL357909

C[C@H](C(=O)O)N(C)C(=O)OC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ AAK1 Q2M2I8 2/20 0.33
▸ MMP13 P45452 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ HDAC6 Q9UBN7 2/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC2 Q92769 1/20 0.33
▸ CA1 P00915 1/20 0.31
▸ CA2 P00918 1/20 0.31
▸ CA7 P43166 1/20 0.31
▸ DGAT1 O75907 1/20 0.30
▸ L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL342692 1.00 AAK1 (0.33) AAK1MMP13MEN1GAAKMT2A
SCHEMBL342693 1.00 AAK1 (0.33) AAK1MMP13MEN1GAAKMT2A
SCHEMBL18419552 0.89 — —
Biphenyl SCHEMBL27530882 0.87 CYP1A2 (0.41) MMP13GAAL3MBTL1
SCHEMBL13006285 0.86 MEN1 (0.31) MEN1GAAKMT2AHDAC6HDAC1
SCHEMBL2264821 0.86 MEN1 (0.31) MEN1GAAKMT2AHDAC6HDAC1
SCHEMBL2264825 0.86 MEN1 (0.31) MEN1GAAKMT2AHDAC6HDAC1
SCHEMBL7876573 0.84 AAK1 (0.32) AAK1MMP13HDAC6HDAC1HDAC2
SCHEMBL17277663 0.84 AAK1 (0.32) AAK1MMP13HDAC6HDAC1HDAC2
SCHEMBL14952039 0.83 AAK1 (0.33) AAK1MMP13HDAC6HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 407 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119684220-A Preparation method of (2R, 5R) -1,2, 5-trimethylpiperazine 江苏宝众宝达药业股份有限公司 2025-03-25 — — CN claimed
CN-109153645-B Process for preparing 6-alkynyl-pyridine derivatives 勃林格殷格翰国际有限公司 2022-06-21 — — CN claimed
US-11053237-B2 Process for the manufacture of 6-alkynyl-pyridine derivatives BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-07-06 — — US claimed
EP-3458441-B1 PROCESS FOR THE MANUFACTURE OF 6-ALKYNYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM INT (DE) 2021-01-20 — — EP claimed
US-20190308967-A1 PROCESS FOR THE MANUFACTURE OF 6-ALKYNYL-PYRIDINE DERIVATIVES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2019-10-10 — — US claimed
US-9458127-B2 Bis-acylated hydroxylamine derivatives CARDIOXYL PHARMACEUTICALS, INC. (US) 2016-10-04 — — US claimed
US-20150197502-A1 Bis-Acylated Hydroxylamine Derivatives THE JOHNS HOPKINS UNIVERSITY 2015-07-16 — — US claimed
US-20260109686-A1 PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS AZKARRA THERAPEUTICS, INC. (US) 2026-04-23 — — US disclosed
US-20260098060-A1 MACROCYCLIC CFTR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2026-04-09 — — US disclosed
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-04-02 — — US disclosed
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-02-12 — — US disclosed
EP-4656201-A2 RAS INHIBITORS Revolution Medicines, Inc. (US) 2025-12-03 — — EP disclosed
US-12472165-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-11-18 — — US disclosed
WO-1992016524-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1992-10-01 — — WO disclosed
US-5142048-A Enzyme inhibitor; carbamoyl group-containing acids FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-08-25 — — US disclosed
US-4921855-A New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-05-01 — — US disclosed
EP-0300189-A2 New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-01-25 — — EP disclosed
US-4533655-A Analgesic dipeptide amides and method of use and compositions thereof STERLING DRUG INC. (US) 1985-08-06 — — US disclosed
US-4260608-A ANTIMICROBIAL, ANTIMITOTIC, AND ANTITUMOR AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1981-04-07 — — US disclosed
EP-0011276-A1 Maytansinoids, their production and use Takeda Chemical Industries, Ltd. (JP) 1980-05-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150197502-A1 Bis-Acylated Hydroxylamine Derivatives CPT1A, TNNI3, NOS2 AAK1 3292/4885MMP13 1620/4885MEN1 3253/4885
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE IL6ST, GFRA3, GFRA1 AAK1 4125/4885MMP13 800/4885MEN1 3255/4885
US-20260098060-A1 MACROCYCLIC CFTR MODULATORS CFTR, CLIC1, ARRB1 AAK1 2966/4885MMP13 4473/4885MEN1 3584/4885
US-11053237-B2 Process for the manufacture of 6-alkynyl-pyridine derivatives ALK, PARP16, ALKBH3 AAK1 408/4885MMP13 4657/4885MEN1 2522/4885
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE GFRA3, IL6ST, GFRA1 AAK1 4137/4885MMP13 848/4885MEN1 3290/4885
US-12472165-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 AAK1 2850/4885MMP13 1017/4885MEN1 1667/4885
US-20260109686-A1 PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS PARP2, PARP1, PARP11 AAK1 2899/4885MMP13 3833/4885MEN1 3994/4885
US-20190308967-A1 PROCESS FOR THE MANUFACTURE OF 6-ALKYNYL-PYRIDINE DERIVATIVES ALK, PARP16, ALKBH3 AAK1 408/4885MMP13 4657/4885MEN1 2522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.