Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300738 | 1.00 | PDGFRB (0.56) | PDGFRBKDRRXRACISD1TTR | |
| SCHEMBL29638301 | 0.90 | FLT3 (0.54) | KDRRXRACISD1TTRPIM1 | |
| SCHEMBL14674946 | 0.90 | FLT3 (0.54) | KDRRXRACISD1TTRPIM1 | |
| SCHEMBL14674947 | 0.90 | FLT3 (0.54) | KDRRXRACISD1TTRPIM1 | |
| SCHEMBL14675079 | 0.87 | PDGFRB (0.64) | PDGFRBKDRPIM1PIM2TGM2 | |
| SCHEMBL14675080 | 0.87 | PDGFRB (0.64) | PDGFRBKDRPIM1PIM2TGM2 | |
| SCHEMBL14679985 | 0.86 | CISD1 (0.49) | PDGFRBKDRRXRACISD1TTR | |
| SCHEMBL29875451 | 0.86 | LRRK2 (0.54) | CISD1TTRPIM1PIM2PLK4 | |
| SCHEMBL1301170 | 0.86 | LRRK2 (0.54) | CISD1TTRPIM1PIM2PLK4 | |
| SCHEMBL1301174 | 0.86 | LRRK2 (0.54) | CISD1TTRPIM1PIM2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | claimed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | claimed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-20110269812-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-11-03 | — | — | US | disclosed |
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | ERBB2, ABL1, IGF1R | PDGFRB 11/4885KDR 81/4885RXRA 1518/4885 |
| US-20110269812-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | SBK3, DMPK, PHKG2 | PDGFRB 920/4885KDR 936/4885RXRA 4383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.