Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.54 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875451 | 1.00 | LRRK2 (0.54) | LRRK2CISD1TTRPIM1PIM2 | |
| SCHEMBL1301174 | 1.00 | LRRK2 (0.54) | LRRK2CISD1TTRPIM1PIM2 | |
| SCHEMBL14674469 | 0.90 | LRRK2 (0.68) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1300997 | 0.90 | LRRK2 (0.68) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8205160 | 0.87 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL250592 | 0.87 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29443853 | 0.87 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL250593 | 0.87 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1300733 | 0.86 | PDGFRB (0.56) | CISD1TTRPIM1PIM2PLK4 | |
| SCHEMBL1300738 | 0.86 | PDGFRB (0.56) | CISD1TTRPIM1PIM2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742121-B2 | Process for the preparation of small molecule inhibitors of MDM2 and intermediates used therein | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-06-03 | — | — | US | claimed |
| US-20130030173-A1 | PROCESS FOR THE PREPARATION OF SMALL MOLECULE INHIBITORS OF MDM2 AND INTERMEDIATES USED THEREIN | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-01-31 | — | — | US | claimed |
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | claimed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | claimed |
| CN-116621765-B | Synthesis method and application of 2-indolone analogue containing alpha, beta-unsaturated ketone | 贵州省天然产物研究中心 | 2023-10-13 | — | — | CN | disclosed |
| CN-116621765-A | Synthesis method and application of 2-indolone analogue containing alpha, beta-unsaturated ketone | 贵州省天然产物研究中心 | 2023-08-22 | — | — | CN | disclosed |
| CN-114057755-B | Preparation method and application of iridoid aglycone-based spiro indolone compound | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-08-30 | — | — | CN | disclosed |
| CN-114057755-A | Preparation method and application of iridoid aglycone-based spiro indolone compound | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-02-18 | — | — | CN | disclosed |
| US-20110269812-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-11-03 | — | — | US | disclosed |
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | disclosed |
| US-7638548-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-12-29 | — | — | US | disclosed |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | LIU JIN-JUN | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269812-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | SBK3, DMPK, PHKG2 | LRRK2 191/4885CISD1 2020/4885TTR 3845/4885 |
| US-20130030173-A1 | PROCESS FOR THE PREPARATION OF SMALL MOLECULE INHIBITORS OF MDM2 AND INTERMEDIATES USED THEREIN | TP53, MDM2, CDKN1A | LRRK2 963/4885CISD1 1459/4885TTR 4399/4885 |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | RB1, XPOT, PDK2 | LRRK2 267/4885CISD1 1183/4885TTR 4413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.