PHKG2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL147422	0.66	4/20
SCHEMBL144979	0.56	4/20
SCHEMBL146734	0.67	3/20
SCHEMBL144651	0.67	3/20
SCHEMBL146677	0.67	3/20
SCHEMBL144378	0.66	3/20
SCHEMBL142020	0.65	3/20
SCHEMBL148704	0.62	3/20
SCHEMBL147730	0.61	3/20
SCHEMBL148478	0.61	3/20
SCHEMBL144118	0.61	3/20
SCHEMBL144615	0.61	3/20
SCHEMBL147715	0.61	3/20
SCHEMBL143818	0.61	3/20
SCHEMBL143827	0.59	3/20
SCHEMBL145924	0.59	3/20
SCHEMBL144183	0.58	3/20
SCHEMBL140610	0.56	3/20
SCHEMBL149330	0.56	3/20
SCHEMBL143148	0.56	3/20

Clinical trials — most relevant to PHKG2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Efficacy of Amlexanox vs. Placebo in Type 2 Diabetic Patients	PHASE2	COMPLETED
Study in Adult Ph-positive ALL	PHASE2	UNKNOWN
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Biological Effects of Quercetin in COPD Phase II	PHASE2	UNKNOWN
A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas	PHASE2	SUSPENDED
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer	PHASE1/PHASE2	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
A Dose-Finding Study of AG-348 in Sickle Cell Disease	EARLY_PHASE1	COMPLETED
GSD VI and GSD IX Natural History	nan	RECRUITING
'Glycogen Storage Diseases (GSDs) in Indian Children- Establishing an Indian GSD (I-GSD) Registry'	nan	RECRUITING
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease	nan	COMPLETED
Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia	nan	UNKNOWN
The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans: A Pilot Study	nan	WITHDRAWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.	nan	NOT_YET_RECRUITING
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PHKG2 binder may also engage these)

Protein	Name	Similarity
Q2KJ16	—	1.000	Q2KJ16 →
Q9DB30	—	1.000	Q9DB30 →
P31325	—	1.000	P31325 →
P07934	—	0.997	P07934 →
O19111	—	0.996	O19111 →
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1	0.996	landscape →
Q4G050	—	0.996	Q4G050 →
P00518	—	0.995	P00518 →
P13286	—	0.995	P13286 →
PHKG1	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0.995	landscape →
O08605	—	0.995	O08605 →
Q66JF3	—	0.994	Q66JF3 →
Q02956	—	0.994	Q02956 →
PRKCZ	Protein kinase C zeta type	0.994	landscape →
Q66I46	—	0.993	Q66I46 →
PSKH1	Serine/threonine-protein kinase H1	0.993	landscape →
Q9ZUZ2	—	0.992	Q9ZUZ2 →
P51138	—	0.992	P51138 →
Q62074	—	0.992	Q62074 →
Q8BRK8	—	0.992	Q8BRK8 →
Q501V0	—	0.992	Q501V0 →
RPS6KB1	Ribosomal protein S6 kinase beta-1	0.992	landscape →
F1M7Y5	—	0.991	F1M7Y5 →
P13234	—	0.991	P13234 →
Q6TJY3	—	0.991	Q6TJY3 →
Q8BSK8	—	0.991	Q8BSK8 →
Q8BHI9	—	0.991	Q8BHI9 →
P09217	—	0.991	P09217 →
Q90XF2	—	0.991	Q90XF2 →
Q8VZD5	—	0.991	Q8VZD5 →