Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 6/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300777 | 1.00 | METTL3 (0.65) | METTL3THRBTSHRHIF1ANOTUM | |
| SCHEMBL12108084 | 0.87 | METTL3 (0.69) | METTL3THRBTSHRHIF1ANOTUM | |
| SCHEMBL1301031 | 0.87 | METTL3 (0.64) | METTL3THRBTSHRHIF1ANOTUM | |
| SCHEMBL1301034 | 0.87 | METTL3 (0.64) | METTL3THRBTSHRHIF1ANOTUM | |
| SCHEMBL1301704 | 0.86 | METTL3 (0.70) | METTL3NOTUMCFDNTRK1MRGPRX4 | |
| SCHEMBL16302717 | 0.85 | METTL3 (0.66) | METTL3THRBTSHRHIF1ACFD | |
| SCHEMBL12108039 | 0.84 | METTL3 (0.65) | METTL3THRBTSHRHIF1ANOTUM | |
| SCHEMBL12107926 | 0.84 | METTL3 (0.72) | METTL3THRBTSHRHIF1A | |
| SCHEMBL1300623 | 0.84 | METTL3 (0.72) | METTL3THRBTSHRHIF1A | |
| SCHEMBL1300379 | 0.84 | METTL3 (0.67) | METTL3THRBTSHRHIF1ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | AARDEA BIOSCIENCES, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | TYMP, SAMHD1, PNP | METTL3 2709/4885THRB 4424/4885TSHR 4868/4885 |
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | TYMP, SAMHD1, PNP | METTL3 2709/4885THRB 4424/4885TSHR 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.