Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.68 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14674469 | 1.00 | LRRK2 (0.68) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1301174 | 0.90 | LRRK2 (0.54) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1301170 | 0.90 | LRRK2 (0.54) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29875451 | 0.90 | LRRK2 (0.54) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14674946 | 0.86 | FLT3 (0.54) | LRRK2RPS6KA3 | |
| SCHEMBL14674947 | 0.86 | FLT3 (0.54) | LRRK2RPS6KA3 | |
| SCHEMBL29638301 | 0.86 | FLT3 (0.54) | LRRK2RPS6KA3 | |
| SCHEMBL14674619 | 0.86 | LRRK2 (0.70) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14674620 | 0.86 | LRRK2 (0.70) | LRRK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14673807 | 0.85 | LRRK2 (0.64) | LRRK2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | claimed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | claimed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-20110269812-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-11-03 | — | — | US | disclosed |
| EP-2350001-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | National University of Singapore (SG) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010044753-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | ERBB2, ABL1, IGF1R | LRRK2 19/4885PSEN1 3380/4885PSEN2 3088/4885 |
| US-20110269812-A1 | NOVEL BENZYLIDENE-INDOLINONE AND THEIR MEDICAL AND DIAGNOSTIC USES | SBK3, DMPK, PHKG2 | LRRK2 191/4885PSEN1 3016/4885PSEN2 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.