Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.43 |
| ▸ | AKT1 | P31749 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TET3 | O43151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.38 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651440 | 0.90 | DRD2 (0.56) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| Hydrochloric Acid SCHEMBL8353081 | 0.89 | DRD2 (0.54) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL17424825 | 0.84 | DRD2 (0.49) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL12219063 | 0.84 | DRD2 (0.49) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL1975025 | 0.81 | HSD11B1 (0.56) | HDAC4HSD11B1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL192358 | 0.80 | SLC6A2 (0.46) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL684402 | 0.80 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL680932 | 0.80 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL681492 | 0.80 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL27594934 | 0.80 | DRD2 (0.59) | DRD2HDAC4HSD11B1AKT1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049546-B1 | DIHYDROFURO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2010-12-29 | — | — | EP | disclosed |