SCHEMBL130126

SCHEMBL130126

COc1ccc(Cl)c(C)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.52
MAPT P10636 2/20 0.48
TSHR P16473 1/20 0.48
NPY1R P25929 1/20 0.48
NPY2R P49146 1/20 0.48
KMT2A Q03164 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
KDM4E B2RXH2 1/20 0.46
POLB P06746 1/20 0.46
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
MEN1 O00255 1/20 0.45
PKM P14618 1/20 0.45
ALDH1A1 P00352 3/20 0.44
GAA P10253 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11184060 0.87 KDM4E (0.49) MCL1MAPTTSHRNPY1RNPY2R
SCHEMBL6564428 0.83 KDM4E (0.56) MCL1KMT2ASMN1; SMN2KDM4EPOLB
SCHEMBL2205828 0.81 MAPT (0.50) MAPTKMT2ASMN1; SMN2POLBCA12
SCHEMBL1145316 0.80 SLC6A4 (0.54) KDM4ECA12CA1CA2CA7
SCHEMBL29768449 0.80 SLC6A4 (0.54) KDM4ECA12CA1CA2CA7
SCHEMBL11087092 0.79 KMT2A (0.50) MCL1KMT2ASMN1; SMN2KDM4EPOLB
SCHEMBL882328 0.79 MCL1 (0.50) MCL1KMT2ASMN1; SMN2KDM4EPOLB
SCHEMBL1000564 0.79 TDP1 (0.44) MAPTTSHRKMT2AKDM4ECA12
SCHEMBL3757525 0.79 MCL1 (0.50) MCL1KMT2ASMN1; SMN2KDM4EPOLB
SCHEMBL19785375 0.78 HSP90AA1 (0.56) MAPTTSHRKMT2AKDM4ECA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 289 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-57193435-A None JP disclosed
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON INC (US) 2026-03-12 US disclosed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 US disclosed
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 US disclosed
WO-2024015055-A1 PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1 AND TREATMENT OF CANCER THRYV THERAPEUTICS INC. (CA) 2024-01-18 WO disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 US disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 US disclosed
US-20230355638-A1 Cyclopentathiophene Carboxamide Derivatives as Platelet Activating Factor Receptor Antagonists BOEHRINGER INGELHEIM INT (DE) 2023-11-09 US disclosed
US-20230355638-A1 Cyclopentathiophene Carboxamide Derivatives as Platelet Activating Factor Receptor Antagonists BOEHRINGER INGELHEIM INT (DE) 2023-11-09 US disclosed
EP-0274867-A2 Pharmaceutically active compounds SCHERING CORPORATION (US) 1988-07-20 EP disclosed
EP-0206751-A2 2-Substituted quinolines, their preparation and use MERCK FROSST CANADA INC. (CA) 1986-12-30 EP disclosed
US-4448971-A Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1984-05-15 US disclosed
EP-0045423-B1 PROCESS FOR THE ALPHA-HALOGENATION OF POSSIBLY SUBSTITUTED METHYL AROMATICS BAYER AG (DE) 1984-02-22 EP disclosed
US-4407811-A Hypoglycemic 5-substituted oxazolidine-2,4-diones PFIZER INC. (US) 1983-10-04 US disclosed
US-4399296-A TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES PFIZER INC. (US) 1983-08-16 US disclosed
US-4367234-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1983-01-04 US disclosed
JP-S57193435-A PRODUCTION OF DIPHENYLAMINE NIPPON KAYAKU CO LTD 1982-11-27 JP disclosed
EP-0045423-A1 Process for the alpha-halogenation of possibly substituted methyl aromatics BAYER AG (DE) 1982-02-10 EP disclosed
US-4198205-A SULFONIC ACID-FREE DISPERSE DYES BASF AKTIENGESELLSCHAFT (DE) 1980-04-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 MCL1 4793/4885MAPT 1152/4885TSHR 2377/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 MCL1 4793/4885MAPT 1152/4885TSHR 2377/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH MCL1 2451/4885MAPT 4803/4885TSHR 437/4885
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFH, CFB, C5 MCL1 4501/4885MAPT 4737/4885TSHR 204/4885
US-11858907-B2 Kinase modulators RPS6KA1, RPS6KA2, PRKAR2A MCL1 552/4885MAPT 3674/4885TSHR 1696/4885
US-20230355638-A1 Cyclopentathiophene Carboxamide Derivatives as Platelet Activating Factor Receptor Antagonists PTAFR, PDGFRA, F3 MCL1 1805/4885MAPT 4477/4885TSHR 361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.