Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014468 | 0.95 | BRD4 (0.46) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13014020 | 0.94 | ADORA3 (0.45) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13014079 | 0.92 | BRD4 (0.49) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13014278 | 0.91 | BRD4 (0.49) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13014460 | 0.89 | ADORA3 (0.44) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13013481 | 0.88 | ADORA3 (0.49) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13013582 | 0.86 | BRD4 (0.47) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13014077 | 0.86 | BRD4 (0.45) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13013490 | 0.85 | ADORA3 (0.48) | BRD4BRD2BRD3BRDTADORA3 | |
| SCHEMBL13014273 | 0.85 | ADORA3 (0.47) | BRD4BRD2BRD3BRDTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |