Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57542 | 0.73 | KDM4E (0.69) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL11506441 | 0.71 | KDM4E (0.67) | KDM4EHTTUSP2MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL31715997 | 0.71 | KDM4E (0.67) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL1613027 | 0.71 | KDM4E (0.67) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL12020235 | 0.71 | TLR7 (0.42) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL6385845 | 0.71 | PTK2B (0.49) | KDM4EHTTMAPTALDH1A1HPGD | |
| SCHEMBL6457986 | 0.70 | KDM4E (0.65) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL13209738 | 0.70 | KDM4E (0.69) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL2537845 | 0.70 | KDM4E (0.64) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL28535854 | 0.70 | KDM4E (0.64) | KDM4EHTTUSP2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258688-A1 | Pyridinone derivatives for treatment of atherosclerosis | SmithKline Beecham Limited (GB) | 2010-12-08 | — | — | EP | disclosed |