Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14961256 | 0.87 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL13017507 | 0.79 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL13017510 | 0.79 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL13017582 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL13017556 | 0.76 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL14961247 | 0.76 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL13063099 | 0.75 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL13017513 | 0.74 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL14747565 | 0.73 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL3452534 | 0.72 | ALDH1A1 (0.39) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130131015-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES | UNIV NORTH CAROLINA STATE (US) | 2013-05-23 | — | — | US | disclosed |
| US-8389732-B2 | Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389732-B2 | Synthesis and regioselective substitution of 6-halo- and 6-alkoxy nicotine derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2013-03-05 | — | — | US | disclosed |
| US-20100331323-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES | COMINS DANIEL L | 2010-12-30 | — | — | US | disclosed |
| US-20100331323-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES | COMINS DANIEL L | 2010-12-30 | — | — | US | disclosed |
| US-7820826-B2 | Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820826-B2 | Synthesis and regioselective substitution of 6-halo-and 6-alkoxy nicotine derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2007126826-A2 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070232665-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO-AND 6-ALKOXY NICOTINE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY | 2007-10-04 | — | — | US | disclosed |
| US-20070232665-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO-AND 6-ALKOXY NICOTINE DERIVATIVES | NORTH CAROLINA STATE UNIVERSITY | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232665-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO-AND 6-ALKOXY NICOTINE DERIVATIVES | CHRNA6, CHRNA7, CHRNA4 | CHRNB2 13/4885CHRNA4 3/4885CHRNB1 9/4885 |
| US-20100331323-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES | CHRNA6, CHRNA7, CHRNA4 | CHRNB2 13/4885CHRNA4 3/4885CHRNB1 9/4885 |
| US-20130131015-A1 | SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO- AND 6-ALKOXY NICOTINE DERIVATIVES | CHRNA6, CHRNA7, CHRNA4 | CHRNB2 13/4885CHRNA4 3/4885CHRNB1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.