Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23563041 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP2D6CYP2C9MAPK9MAPK10 | |
| SCHEMBL5956410 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP2D6CYP2C9GAAHTT | |
| SCHEMBL18635357 | 0.78 | CYP11B2 (0.44) | PTPN11MAPK9MAPK10MAPK8HDAC1 | |
| SCHEMBL25509137 | 0.75 | KCNQ2 (0.31) | SMN1; SMN2DPP8DPP9KCNQ2 | |
| SCHEMBL30806569 | 0.75 | MAPK9 (0.37) | PTPN11MAPK9MAPK10MAPK8HDAC1 | |
| SCHEMBL13019291 | 0.74 | MTNR1A (0.38) | SMN1; SMN2CYP2D6CYP2C9HDAC1HDAC6 | |
| SCHEMBL19495311 | 0.74 | CYP1A2 (0.48) | PTPN11MAPK9MAPK10MAPK8HDAC1 | |
| SCHEMBL5956393 | 0.73 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP2D6CYP2C9CHRM1DRD2 | |
| SCHEMBL29896794 | 0.73 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP2D6CYP2C9CHRM1DRD2 | |
| SCHEMBL17244886 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037577-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2018-02-08 | — | — | US | disclosed |
| US-9796706-B2 | Inhibitors of Jun N-terminal kinase | IMAGO PHARMACEUTICALS, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170107209-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | US | disclosed |
| US-20150259330-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | IMAGO PHARMACEUTICALS, INC. (US) | 2015-09-17 | — | — | US | disclosed |
| US-9073891-B2 | Inhibitors of Jun N-terminal kinase | IMAGO PHARMACEUTICALS, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20130072494-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | ELAN PHARMACEUTICALS, INC. | 2013-03-21 | — | — | US | disclosed |
| US-20100331335-A1 | Inhibitors of Jun N-Terminal Kinase | ELAN PHARMACETICALS, INC. | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259330-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | SMN1; SMN2 2311/4885CYP2D6 2186/4885CYP2C9 3780/4885 |
| US-20170107209-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | SMN1; SMN2 2311/4885CYP2D6 2186/4885CYP2C9 3780/4885 |
| US-20180037577-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | SMN1; SMN2 2311/4885CYP2D6 2186/4885CYP2C9 3780/4885 |
| US-20130072494-A1 | INHIBITORS OF JUN N-TERMINAL KINASE | CHUK, MAPK6, MAPK3 | SMN1; SMN2 2311/4885CYP2D6 2186/4885CYP2C9 3780/4885 |
| US-20100331335-A1 | Inhibitors of Jun N-Terminal Kinase | CHUK, MAPK6, MAPK3 | SMN1; SMN2 2311/4885CYP2D6 2186/4885CYP2C9 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.