Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222001 | 0.84 | TDP1 (0.64) | TDP1SMN1; SMN2TSHRALDH1A1CYP1A2 | |
| SCHEMBL18887676 | 0.81 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1CYP1A2 | |
| SCHEMBL3305095 | 0.80 | TDP1 (0.64) | TDP1SMN1; SMN2TSHRALDH1A1CYP1A2 | |
| SCHEMBL472112 | 0.78 | TDP1 (1.00) | TDP1SMN1; SMN2TSHRALDH1A1KMT2A | |
| SCHEMBL3837781 | 0.77 | CYP3A4 (0.63) | TDP1SMN1; SMN2TSHRALDH1A1CYP1A2 | |
| SCHEMBL7119559 | 0.76 | TDP1 (0.58) | TDP1SMN1; SMN2TSHRALDH1A1CYP1A2 | |
| SCHEMBL28032029 | 0.76 | TDP1 (0.58) | TDP1SMN1; SMN2TSHRALDH1A1CYP1A2 | |
| SCHEMBL9550119 | 0.72 | TDP1 (0.78) | TDP1SMN1; SMN2TSHRALDH1A1KMT2A | |
| SCHEMBL700469 | 0.72 | TSHR (1.00) | TDP1SMN1; SMN2TSHRALDH1A1MEN1 | |
| SCHEMBL29538967 | 0.72 | TSHR (1.00) | TDP1SMN1; SMN2TSHRALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | RAB1A, COPB1, GOLT1B | TDP1 3089/4885SMN1; SMN2 69/4885TSHR 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.