Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Diamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.77 |
| ▸ | THPO | P40225 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.77 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diamide SCHEMBL39340 | 0.87 | TSHR (1.00) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL103289 | 0.87 | TSHR (1.00) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL13680778 | 0.87 | TSHR (1.00) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL2036888 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL1772314 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL3793192 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL8186446 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL1681704 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL9634763 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 | |
| Diamide SCHEMBL2299006 | 0.84 | TSHR (0.93) | ALDH1A1TSHRNFKB1THPOHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382293-B1 | SOLVENT-LESS PREPARATION OF POLYOLS BY OZONOLYSIS | BATTELLE MEMORIAL INSTITUTE (US) | 2019-01-16 | — | — | EP | claimed |
| EP-2382292-B1 | PRE-ESTERIFICATION OF PRIMARY POLYOLS TO IMPROVE SOLUBILITY IN SOLVENTS USED IN POLYOL PROCESS | BATTELLE MEMORIAL INSTITUTE (US) | 2018-02-21 | — | — | EP | claimed |
| EP-2308955-B1 | METHODS FOR PRODUCTION OF POLYOLS FROM OILS AND THEIR USE IN THE PRODUCTION OF POLYESTERS AND POLYURETHANES | BATTELLE MEMORIAL INSTITUTE (US) | 2017-02-22 | — | — | EP | claimed |
| US-8877952-B2 | Pre-esterification of primary polyols to improve solubility in solvents used in the polyol process | BATTELLE MEMORIAL INSTITUTE (US) | 2014-11-04 | — | — | US | claimed |
| US-8624047-B2 | Solvent-less preparation of polyols by ozonolysis | BATTELLE MEMORIAL INSTITUTE (US) | 2014-01-07 | — | — | US | claimed |
| US-8178703-B2 | Methods for production of polyols from oils and their use in the production of polyesters and polyurethanes | BATTELLE MEMORIAL INSTITUTE (US) | 2012-05-15 | — | — | US | claimed |
| US-20110269981-A1 | Pre-Esterification Of Primary Polyols To Improve Solubility In Solvents Used In The Polyol Process | BATTELLE MEMORIAL INSTITUTE (US) | 2011-11-03 | — | — | US | claimed |
| US-20110269978-A1 | Solvent-less Preparation of Polyols by Ozonolysis | BATTELLE MEMORIAL INSTITUTE (US) | 2011-11-03 | — | — | US | claimed |
| EP-2382293-A1 | SOLVENT-LESS PREPARATION OF POLYOLS BY OZONOLYSIS | Battelle Memorial Institute (US) | 2011-11-02 | — | — | EP | claimed |
| EP-2382292-A1 | PRE-ESTERIFICATION OF PRIMARY POLYOLS TO IMPROVE SOLUBILITY IN SOLVENTS USED IN POLYOL PROCESS | Battelle Memorial Institute (US) | 2011-11-02 | — | — | EP | claimed |
| US-20110237812-A1 | METHODS FOR PRODUCTION OF POLYOLS FROM OILS AND THEIR USE IN THE PRODUCTION OF POLYESTERS AND POLYURETHANES | BATTELLE MEMORIAL INSTITUTE (US) | 2011-09-29 | — | — | US | claimed |
| EP-2308955-A1 | Methods for production of polyols from oils and their use in the production of polyesters and polyurethanes | BATTELLE MEMORIAL INSTITUTE (US) | 2011-04-13 | — | — | EP | claimed |
| WO-2010078493-A1 | SOLVENT-LESS PREPARATION OF POLYOLS BY OZONOLYSIS | BATTELLE MEMORIAL INSTITUTE (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010078491-A1 | PRE-ESTERIFICATION OF PRIMARY POLYOLS TO IMPROVE SOLUBILITY IN SOLVENTS USED IN POLYOL PROCESS | BATTELLE MEMORIAL INSTITUTE (US) | 2010-07-08 | — | — | WO | claimed |
| US-20090216040-A1 | Methods For Production Of Polyols From Oils And Their Use In the Production of Polyesters and Polyurethanes | BATTELLE MEMORIAL INSTITUTE (US) | 2009-08-27 | — | — | US | claimed |
| EP-1883690-A2 | METHODS FOR PRODUCTION OF POLYOLS FROM OILS AND THEIR USE IN THE PRODUCTION OF POLYESTERS AND POLYURETHANES | BATTELLE MEMORIAL INSTITUTE (US) | 2008-02-06 | — | — | EP | claimed |
| WO-2007027223-A2 | METHODS FOR PRODUCTION OF POLYOLS FROM OILS AND THEIR USE IN THE PRODUCTION OF POLYESTERS AND POLYURETHANES | BATTELLE MEMORIAL INSTITUTE (US) | 2007-03-08 | — | — | WO | claimed |
| CN-115044035-A | Sequence-regular polyesteramide and one-pot preparation method thereof | 东华大学 | 2022-09-13 | — | — | CN | disclosed |
| EP-2308955-B1 | METHODS FOR PRODUCTION OF POLYOLS FROM OILS AND THEIR USE IN THE PRODUCTION OF POLYESTERS AND POLYURETHANES | BATTELLE MEMORIAL INSTITUTE (US) | 2017-02-22 | — | — | EP | disclosed |
| EP-2308955-A1 | Methods for production of polyols from oils and their use in the production of polyesters and polyurethanes | BATTELLE MEMORIAL INSTITUTE (US) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269978-A1 | Solvent-less Preparation of Polyols by Ozonolysis | MGLL, PUF60, DAGLA | ALDH1A1 3814/4885TSHR 4522/4885NFKB1 3788/4885 |
| US-20090216040-A1 | Methods For Production Of Polyols From Oils And Their Use In the Production of Polyesters and Polyurethanes | FASN, MGLL, PUF60 | ALDH1A1 2170/4885TSHR 4494/4885NFKB1 3843/4885 |
| US-20110237812-A1 | METHODS FOR PRODUCTION OF POLYOLS FROM OILS AND THEIR USE IN THE PRODUCTION OF POLYESTERS AND POLYURETHANES | FASN, MGLL, PUF60 | ALDH1A1 2170/4885TSHR 4494/4885NFKB1 3843/4885 |
| US-20110269981-A1 | Pre-Esterification Of Primary Polyols To Improve Solubility In Solvents Used In The Polyol Process | MGLL, FASN, ELOVL1 | ALDH1A1 2075/4885TSHR 4652/4885NFKB1 520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.