SCHEMBL13024869

SCHEMBL13024869

C=CC(=O)OCCC(F)(OC(F)(F)C(F)(OC(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F)C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.40
ALDH1A1 P00352 4/20 0.40
TP53 P04637 3/20 0.40
HIF1A Q16665 3/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP3A4 P08684 2/20 0.37
THRB P10828 2/20 0.35
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13024871 0.87 TSHR (0.40) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL30360196 0.86 ALDH1A1 (0.39) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL13096929 0.86 ALDH1A1 (0.39) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL26460443 0.82 ALDH1A1 (0.40) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL13024878 0.80 THRB (0.39) TSHRTHRB
SCHEMBL13096928 0.78 ALDH1A1 (0.44) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL25343675 0.77 TSHR (0.41) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL25343423 0.77 ALDH1A1 (0.38) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL13024765 0.76
SCHEMBL13024771 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7838190-B2 Electrophotographic photosensitive member with surface layer of fluororesin particles and polyolefin with perfluoroalkyl group CANON KABUSHIKI KAISHA (JP) 2010-11-23 US disclosed
US-7799496-B2 Electrophotographic photosensitive member, method of manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-09-21 US disclosed
US-7704657-B2 Electrophotographic photosensitive member, method of manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-04-27 US disclosed
US-20090180800-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-07-16 US disclosed
US-7553594-B2 Electrophotographic photosensitive member, method of manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-06-30 US disclosed
US-20090130576-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-05-21 US disclosed
US-20080199794-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-08-21 US disclosed
US-20080199795-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-08-21 US disclosed