Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13025166 | 0.86 | HSPD1 (0.58) | P2RX4L3MBTL1SMN1; SMN2POLBMAPK1 | |
| SCHEMBL13025171 | 0.84 | KDM4E (0.51) | P2RX4GABRA5TDP1L3MBTL1MAPT | |
| SCHEMBL10314603 | 0.83 | P2RX4 (0.67) | P2RX4GABRA5TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL13025168 | 0.82 | PDE1A (0.41) | P2RX4L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL13025167 | 0.81 | SRC (0.44) | SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL2863880 | 0.80 | P2RX4 (0.62) | P2RX4GABRA5TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27836563 | 0.79 | P2RX4 (0.61) | P2RX4GABRA5TDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL13025172 | 0.79 | KDM4E (0.46) | P2RX4SMN1; SMN2GAAMAPK1MEN1 | |
| SCHEMBL13025207 | 0.78 | P2RX4 (0.43) | P2RX4GABRA5SMN1; SMN2POLBGAA | |
| SCHEMBL14160793 | 0.76 | P2RX4 (1.00) | P2RX4GABRA5TDP1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842701-B2 | Pyrazoloquinolone derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-30 | — | — | US | disclosed |
| US-20070281963-A1 | Pyrazoloquinolone Derivative And Use Thereof | TAKEDA PHARMACEUTICAL COMPANY (JP) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281963-A1 | Pyrazoloquinolone Derivative And Use Thereof | MAP3K20, MAP4K5, MAP4K3 | P2RX4 718/4885GABRA5 2689/4885TDP1 2985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.