HSPD1

60 kDa heat shock protein, mitochondrial · P10809 · HSPD1 on Sugi Atlas →

83,306 patent compounds predicted against HSPD1, 66,179 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
4'-Hydroxychalcone 4'-Hydroxychalcone (SCHEMBL127606) 1.00 3/20
Tribromsalan Tribromsalan (SCHEMBL121315) 0.79 3/20
Chalcone Chalcone (SCHEMBL27580) 0.78 3/20
Chalcone Chalcone (SCHEMBL27581) 0.78 3/20
SCHEMBL67608 SCHEMBL67608 0.48 3/20
Cholecalciferol Cholecalciferol (SCHEMBL3126) 1.00 2/20
Cholecalciferol Cholecalciferol (SCHEMBL3127) 1.00 2/20
Ergocalciferol Ergocalciferol (SCHEMBL3420) 1.00 2/20
Ergocalciferol Ergocalciferol (SCHEMBL3421) 1.00 2/20
Ergocalciferol Ergocalciferol (SCHEMBL3422) 1.00 2/20
Cholecalciferol Cholecalciferol (SCHEMBL15694) 1.00 2/20
Cholecalciferol Cholecalciferol (SCHEMBL15695) 1.00 2/20
Benzethonium Benzethonium (SCHEMBL21713) 1.00 2/20
Menadione Menadione (SCHEMBL25970) 1.00 2/20
Plumbagin Plumbagin (SCHEMBL34186) 1.00 2/20
Aurintricarboxylic Acid Aurintricarboxylic Acid (SCHEMBL98495) 1.00 2/20
Evans Blue Free Acid Evans Blue Free Acid (SCHEMBL103701) 1.00 2/20
Closantel Closantel (SCHEMBL116617) 1.00 2/20
Benzethonium Benzethonium (SCHEMBL122985) 1.00 2/20
Eprinomectin Eprinomectin (SCHEMBL120548) 0.98 2/20

Clinical trials — most relevant to HSPD1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease PHASE3RECRUITING
Biologic Correlative Taxotere/AC PHASE2COMPLETED
OGX-427 in Castration Resistant Prostate Cancer Patients PHASE2COMPLETED
17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease PHASE2COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma PHASE2COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies PHASE1WITHDRAWN
Study of the Effects of Temperature on Metabolism in Human Muscle PHASE1COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas PHASE1COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1 EARLY_PHASE1RECRUITING
Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide nanRECRUITING
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk nanCOMPLETED
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
Effects of Acute Energy Deficit and Aerobic Exercise on Muscle Quality nanCOMPLETED
Calorie Restriction and Brain Function in Mild Cognitive Impairment nanCOMPLETED
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis nanCOMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study) nanCOMPLETED
Local Heat-Stress as a Mechanism of Hearing Preservation nanWITHDRAWN
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
Human Adaptation to High Altitude nanUNKNOWN
Mitoquines in COPD nanUNKNOWN
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HSPD1 binder may also engage these)

ProteinNameSimilarity
P18687 1.000 P18687 →
Q5NVM5 1.000 Q5NVM5 →
P63038 1.000 P63038 →
A3QA46 1.000 A3QA46 →
A5UH48 1.000 A5UH48 →
Q8PPZ1 1.000 Q8PPZ1 →
Q9XAU7 1.000 Q9XAU7 →
Q15PD3 1.000 Q15PD3 →
B8H163 1.000 B8H163 →
A0L4C9 1.000 A0L4C9 →
Q2NY29 1.000 Q2NY29 →
A7NE88 1.000 A7NE88 →
Q0BKF7 1.000 Q0BKF7 →
A6U6I5 1.000 A6U6I5 →
C4K477 1.000 C4K477 →
P31681 1.000 P31681 →
Q2RWV4 1.000 Q2RWV4 →
Q7MAZ7 1.000 Q7MAZ7 →
P35469 1.000 P35469 →
P19882 1.000 P19882 →
O66196 1.000 O66196 →
Q814B0 1.000 Q814B0 →
P22879 1.000 P22879 →
Q0AJH9 1.000 Q0AJH9 →
B0B9L8 1.000 B0B9L8 →
P63039 1.000 P63039 →
B8CID3 1.000 B8CID3 →
B9DW28 1.000 B9DW28 →
A1K436 1.000 A1K436 →
C1CGD7 1.000 C1CGD7 →