Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.61 |
| ▸ | EDNRB | P24530 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | ERCC5 | P28715 | 3/20 | 0.54 |
| ▸ | FEN1 | P39748 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061448 | 0.86 | L3MBTL1 (0.65) | P2RX4EDNRBKDM4EMAPK1HTT | |
| SCHEMBL10314603 | 0.83 | P2RX4 (0.67) | P2RX4KDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2863880 | 0.80 | P2RX4 (0.62) | P2RX4KDM4EMAPK1HTTSMN1; SMN2 | |
| SCHEMBL27724204 | 0.79 | ERCC5 (0.76) | ERCC5FEN1 | |
| SCHEMBL13025165 | 0.79 | P2RX4 (0.61) | P2RX4EDNRBMAPK1SMN1; SMN2CHRM1 | |
| SCHEMBL3402714 | 0.78 | EDNRB (0.51) | P2RX4EDNRBKDM4EMAPK1HTT | |
| SCHEMBL28312049 | 0.78 | P2RX4 (0.57) | P2RX4EDNRBKDM4EMAPK1HTT | |
| SCHEMBL18582662 | 0.77 | L3MBTL1 (0.71) | KDM4EHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3402710 | 0.77 | EDNRB (0.50) | P2RX4EDNRBKDM4EMAPK1HTT | |
| SCHEMBL14160793 | 0.76 | P2RX4 (1.00) | P2RX4MAPK1SMN1; SMN2CHRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| CN-102015705-A | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2011-04-13 | — | — | CN | disclosed |