Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13029974 | 0.93 | TLR2 (0.42) | TLR2ALDH1A1LMNATLR4MAPT | |
| SCHEMBL13030041 | 0.93 | TLR2 (0.41) | TLR2ALDH1A1LMNATLR4MAPT | |
| SCHEMBL9697547 | 0.92 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTMAPK1PRKCA | |
| SCHEMBL13030065 | 0.89 | TLR2 (0.43) | TLR2ALDH1A1LMNATLR4PPARG | |
| SCHEMBL13030064 | 0.89 | TLR2 (0.39) | TLR2ALDH1A1LMNATLR4MAPT | |
| SCHEMBL13786816 | 0.89 | TLR2 (0.40) | TLR2ALDH1A1LMNATLR4MAPT | |
| SCHEMBL13030040 | 0.88 | TLR2 (0.39) | TLR2ALDH1A1LMNATLR4MAPT | |
| SCHEMBL13030034 | 0.86 | TLR2 (0.39) | TLR2ALDH1A1LMNATLR4PPARG | |
| SCHEMBL13030043 | 0.86 | TLR2 (0.46) | TLR2TLR4 | |
| SCHEMBL30994622 | 0.84 | LMNA (0.37) | TLR2ALDH1A1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7833993-B2 | Immunomodulatory compounds and methods of use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-7560584-B2 | Immunomodulatory compounds and methods of use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-07-14 | — | — | US | disclosed |