Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TOP1 | P11387 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30139976 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2BCHEPARP1 | |
| SCHEMBL4954320 | 0.85 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2BCHEKDM4E | |
| SCHEMBL14278922 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2BCHEKDM4E | |
| SCHEMBL15110136 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2BCHEKDM4E | |
| SCHEMBL20032699 | 0.82 | TLR9 (0.60) | NPC1RAB9ASMN1; SMN2BCHEPARP1 | |
| SCHEMBL20032700 | 0.82 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2BCHEKDM4E | |
| SCHEMBL14730878 | 0.82 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2BCHEMAPT | |
| SCHEMBL1976848 | 0.80 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2BCHEKDM4E | |
| SCHEMBL17634104 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2BCHEKDM4E | |
| SCHEMBL24596471 | 0.80 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2BCHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197900-B1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME (US) | 2020-02-12 | — | — | EP | disclosed |
| CN-105873914-B | Substituted quinoxaline derivatives as pest control agents | 拜耳作物科学股份公司 | 2018-10-19 | — | — | CN | disclosed |
| US-9969752-B2 | Inhibitors of HIF prolyl hydroxylase | MERCK SHARP & DOHME CORP. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170233412-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2017-08-17 | — | — | US | disclosed |
| EP-3197900-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049099-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |
| EP-1973386-B1 | LIGHT-EMITTING DEVICE AND ELECTRONIC DEVICE | SEMICONDUCTOR ENERGY LAB (JP) | 2015-11-11 | — | — | EP | disclosed |
| US-20140034982-A1 | LIGHT-EMITTING DEVICE | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2014-02-06 | — | — | US | disclosed |
| EP-2113133-B1 | LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND QUINOXALINE DERIVATIVE | SEMICONDUCTOR ENERGY LAB (JP) | 2013-04-24 | — | — | EP | disclosed |
| EP-2573075-A1 | Light-emitting element, light-emitting device, electronic device, and quinoxaline derivative | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2013-03-27 | — | — | EP | disclosed |
| US-8362472-B2 | Light-emitting element, light-emitting device, electronic device and quinoxaline derivative | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2013-01-29 | — | — | US | disclosed |
| US-8053980-B2 | Light-emitting device and electronic device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20110121721-A1 | Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2011-05-26 | — | — | US | disclosed |
| US-7875879-B2 | Light-emitting element, light-emitting device, electronic device and quinoxaline derivative | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| EP-2113133-A1 | LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND QUINOXALINE DERIVATIVE | Semiconductor Energy Laboratory Co, Ltd. (JP) | 2009-11-04 | — | — | EP | disclosed |
| US-20090114926-A1 | Light-emitting device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2009-05-07 | — | — | US | disclosed |
| US-20080231177-A1 | Light-Emitting Device and Electronic Device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2008-09-25 | — | — | US | disclosed |
| EP-1973386-A2 | Light-emitting device and electronic device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2008-09-24 | — | — | EP | disclosed |
| US-20080217608-A1 | Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2008-09-11 | — | — | US | disclosed |
| WO-2008102713-A1 | LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE AND QUINOXALINE DERIVATIVE | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233412-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | HIF1AN, HIF1A, EGLN2 | NPC1 525/4885RAB9A 2939/4885SMN1; SMN2 3682/4885 |
| US-20110121721-A1 | Light-Emitting Element, Light-Emitting Device, Electronic Device and Quinoxaline Derivative | SLC1A2, NQO1, KCNE1 | NPC1 3991/4885RAB9A 2020/4885SMN1; SMN2 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.