Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | ATR | Q13535 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15110565 | 0.84 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2JAK2TP53 | |
| SCHEMBL30139976 | 0.82 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2BCHEKMT2A | |
| SCHEMBL1303359 | 0.82 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2BCHEKMT2A | |
| SCHEMBL20032700 | 0.81 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2BCHEALDH1A1 | |
| SCHEMBL20032699 | 0.81 | TLR9 (0.60) | NPC1RAB9ASMN1; SMN2BCHEALDH1A1 | |
| SCHEMBL1416671 | 0.79 | CTSS (0.54) | NPC1RAB9AIDO1SMN1; SMN2TP53 | |
| SCHEMBL29746381 | 0.79 | CTSS (0.54) | NPC1RAB9AIDO1SMN1; SMN2TP53 | |
| SCHEMBL15112605 | 0.79 | BCHE (0.68) | NPC1RAB9ASMN1; SMN2JAK2TP53 | |
| SCHEMBL15111910 | 0.78 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2JAK2TP53 | |
| SCHEMBL12938493 | 0.78 | ADORA2A (0.60) | IDO1CTSSADORA2AADORA1SCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744788-B1 | BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2016-10-19 | — | — | EP | disclosed |
| US-9126976-B2 | Substituted benzopiperazines as CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-09-08 | — | — | US | disclosed |
| US-9126976-B2 | Substituted benzopiperazines as CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20140357632-A1 | BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS | MERCK SHARP & DOHME LLC | 2014-12-04 | — | — | US | disclosed |
| US-20140357632-A1 | BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS | MERCK SHARP & DOHME LLC | 2014-12-04 | — | — | US | disclosed |
| WO-2013028382-A1 | BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357632-A1 | BENZOPIPERAZINE DERIVATIVES AS CETP INHIBITORS | CETP, MTTP, HDLBP | NPC1 9/4885RAB9A 4638/4885ATR 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.