Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | EDNRB | P24530 | 5/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13035842 | 0.85 | EDNRB (0.48) | EDNRBMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3481278 | 0.85 | KCNA5 (0.54) | PDE9APDE1CEDNRBMEN1KMT2A | |
| SCHEMBL3622871 | 0.84 | EDNRB (0.45) | PDE9APDE1CEDNRBMEN1KMT2A | |
| SCHEMBL4846578 | 0.77 | ADORA2A (0.48) | MEN1KMT2AALDH1A1USP2CYP1A2 | |
| SCHEMBL19577092 | 0.73 | KDM4E (0.50) | MEN1KMT2AALDH1A1USP2TSHR | |
| SCHEMBL2641389 | 0.71 | EDNRB (0.47) | EDNRBALDH1A1MAPTMAPK1KCNA5 | |
| SCHEMBL11451983 | 0.70 | HTR3A (0.86) | PDE9APDE1CHTR3AALDH1A1USP2 | |
| SCHEMBL3622694 | 0.69 | KCNA5 (0.51) | KCNA5KCNH2KDM4E | |
| SCHEMBL2863880 | 0.69 | P2RX4 (0.62) | PDE9APDE1CMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL3619565 | 0.69 | EDNRB (0.46) | EDNRBMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825131-B2 | Quinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20070078154-A1 | Quinoline potassium channel inhibitors | MERCK SHARP & DOHME CORP. | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078154-A1 | Quinoline potassium channel inhibitors | KCNQ2, KCNQ1, KCNJ2 | PDE9A 1895/4885PDE1C 889/4885HTR3A 2244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.