Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3060767 | 0.82 | HPGD (0.55) | ADORA2AADORA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3052703 | 0.82 | HPGD (0.55) | ADORA2AADORA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL13035840 | 0.77 | PDE9A (0.55) | ALDH1A1KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL8076484 | 0.75 | AR (0.50) | ADORA2AADORA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL4850780 | 0.74 | EGFR (0.45) | ALDH1A1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13035842 | 0.70 | EDNRB (0.48) | ALDH1A1KMT2AMEN1MAPK1NPSR1 | |
| SCHEMBL29961535 | 0.70 | ALDH1A1 (0.40) | ADORA2AADORA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3481278 | 0.69 | KCNA5 (0.54) | ALDH1A1KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL3622871 | 0.68 | EDNRB (0.45) | ALDH1A1KMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL15018232 | 0.68 | ALDH1A1 (0.49) | ADORA2AADORA1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358250-B2 | Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1768982-A2 | PYROLO [2,3-D] PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY | Amgen Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20060040965-A1 | Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity | AMGEN INC. | 2006-02-23 | — | — | US | disclosed |
| WO-2006004703-A2 | PYRROLO[2,3-d]PYRIMIDINES THAT MODULATE ACK1 AND LCK ACTIVITY | AMGEN INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040965-A1 | Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity | LCK, ADCK1, DCK | ADORA2A 1703/4885ADORA1 3163/4885ALDH1A1 4270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.