Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 6/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262747 | 0.82 | DYRK1A (0.46) | DYRK1AELANEGSK3BAPPSNCA | |
| SCHEMBL13044512 | 0.80 | DYRK1A (0.47) | DYRK1AELANECCNT1PIM1CCNA2 | |
| SCHEMBL13168783 | 0.80 | CCNT1 (0.47) | DYRK1AELANECCNT1PIM1CCNA2 | |
| SCHEMBL1092197 | 0.79 | DYRK1A (0.43) | DYRK1AELANECCNT1PIM1CCNA2 | |
| SCHEMBL4569765 | 0.79 | DYRK1A (0.46) | DYRK1AELANECCNT1PIM1CCNA2 | |
| SCHEMBL4717733 | 0.79 | HTR6 (0.44) | ELANECDK2CDK1CCNB1CCNB2 | |
| SCHEMBL17500280 | 0.77 | ELANE (0.36) | ELANEAPPSNCA | |
| SCHEMBL19169097 | 0.77 | HTR6 (0.38) | ELANECDK2APPSNCAHTR6 | |
| SCHEMBL14678667 | 0.76 | DYRK1A (0.43) | DYRK1ACCNT1PIM1CCNA2CDK2 | |
| SCHEMBL967806 | 0.76 | HTR2A (0.57) | DYRK1ACCNT1PIM1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445497-B1 | Use of derivatives of indoles for the treatment of cancer | CENTRE NAT DE LA RECH SCIENT (C N R S ) (FR) | 2017-08-02 | — | — | EP | disclosed |
| WO-2010150211-A2 | USE OF DERIVATIVES OF INDOLES FOR THE TREATMENT OF CANCER | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-12-29 | — | — | WO | disclosed |