Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12845394 | 0.91 | MEN1 (0.55) | PTGS2CDK2PTGS1MEN1LMNA | |
| SCHEMBL12845384 | 0.89 | PTGS2 (0.48) | PTGS2CDK2PTGS1MEN1LMNA | |
| SCHEMBL12845350 | 0.87 | CDK2 (0.47) | PTGS2CDK2PTGS1MEN1KMT2A | |
| SCHEMBL12845382 | 0.86 | MTNR1A (0.54) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL12845698 | 0.86 | PTGS2 (0.47) | PTGS2CDK2PTGS1MEN1LMNA | |
| SCHEMBL12845784 | 0.86 | HTR2A (0.51) | PTGS2CDK2MEN1LMNAKMT2A | |
| SCHEMBL12845780 | 0.85 | GSK3B (0.49) | PTGS2CDK2PTGS1MEN1LMNA | |
| SCHEMBL12845611 | 0.85 | HRH3 (0.49) | PTGS2CDK2MEN1KMT2AHRH3 | |
| SCHEMBL12845701 | 0.85 | CDK2 (0.48) | PTGS2CDK2PTGS1MEN1LMNA | |
| SCHEMBL12845595 | 0.84 | CDK2 (0.48) | PTGS2CDK2PTGS1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834016-B2 | Inhibitors of the interaction between MDM2 and p53 | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-16 | — | — | US | disclosed |
| US-7834016-B2 | Inhibitors of the interaction between MDM2 and p53 | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-16 | — | — | US | disclosed |
| US-20080039472-A1 | Inhibitors of the Interaction Between Mdm2 and P53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039472-A1 | Inhibitors of the Interaction Between Mdm2 and P53 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039472-A1 | Inhibitors of the Interaction Between Mdm2 and P53 | TP53, MDM2, TP53BP1 | PTGS2 3159/4885CDK2 36/4885PTGS1 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.