Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | XDH | P47989 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21227043 | 0.84 | KDM4E (0.64) | LMNAKDM4ESMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL16271680 | 0.83 | LMNA (1.00) | LMNAXDHESR1KDM4ESMN1; SMN2 | |
| SCHEMBL16380546 | 0.83 | LMNA (0.73) | LMNAXDHESR1KDM4ESMN1; SMN2 | |
| SCHEMBL2627826 | 0.79 | LMNA (0.68) | LMNAXDHESR1KDM4ESMN1; SMN2 | |
| SCHEMBL21238277 | 0.75 | MMP1 (0.43) | LMNAKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL11725688 | 0.74 | LMNA (0.73) | LMNAXDHESR1KDM4ESMN1; SMN2 | |
| SCHEMBL24283626 | 0.72 | LMNA (0.57) | LMNAXDHESR1KDM4ESMN1; SMN2 | |
| SCHEMBL21298743 | 0.72 | LMNA (0.57) | LMNAXDHESR1KDM4ESMN1; SMN2 | |
| SCHEMBL21298711 | 0.72 | LMNA (0.57) | LMNAESR1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6801136 | 0.69 | LMNA (0.54) | LMNAESR1SMN1; SMN2TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010147776-A1 | SUBSTITUTED -1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | MERCK SHARP & DOHME CORP. (US) | 2010-12-23 | — | — | WO | disclosed |