Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2673406 | 0.77 | NPSR1 (0.58) | ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9671156 | 0.74 | KDM4E (0.83) | HRH3ALDH1A1KDM4ESMN1; SMN2LSS | |
| SCHEMBL30020230 | 0.73 | CTSL (0.52) | KDM4CKMT2A | |
| SCHEMBL12359378 | 0.72 | HRH3 (0.73) | HRH3ALDH1A1KDM4ESMN1; SMN2LSS | |
| SCHEMBL10095164 | 0.71 | KDM4E (0.63) | ALDH1A1KDM4ELMNAPOLBL3MBTL1 | |
| SCHEMBL3137954 | 0.71 | HRH3 (0.67) | HRH3ALDH1A1KDM4ESMN1; SMN2LSS | |
| SCHEMBL110784 | 0.71 | KEAP1 (0.83) | HRH3ALDH1A1KDM4ESMN1; SMN2LSS | |
| SCHEMBL3260775 | 0.71 | HRH3 (0.71) | HRH3ALDH1A1KDM4ESMN1; SMN2LSS | |
| SCHEMBL13045491 | 0.69 | CA12 (0.53) | ALDH1A1KDM4ESMN1; SMN2LMNAPOLB | |
| SCHEMBL12844521 | 0.69 | HRH3 (0.80) | HRH3ALDH1A1KDM4ESMN1; SMN2LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136804-A1 | PYRIMIDINE DERIVATIVES FOR USE AS ANTIBIOTICS | ASTON UNIVERSITY (GB) | 2010-12-02 | — | — | WO | disclosed |