Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LOX | P28300 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13174198 | 0.81 | HSD17B10 (0.44) | GRM5LRRK2GAAL3MBTL1DYRK1A | |
| SCHEMBL22923901 | 0.75 | LRRK2 (0.54) | LRRK2DYRK1APRKD3MAP4K4CLK2 | |
| SCHEMBL22609952 | 0.73 | CHUK (0.49) | ALDH1A1RAB9AGRM5LRRK2DYRK1A | |
| SCHEMBL28318061 | 0.69 | JAK2 (0.54) | ALDH1A1RAB9ALRRK2GAAL3MBTL1 | |
| SCHEMBL11471452 | 0.68 | ADORA1 (0.49) | NPC1ALDH1A1TP53LOXRAB9A | |
| SCHEMBL743277 | 0.68 | LRRK2 (0.46) | ALDH1A1RAB9AGRM5LRRK2DYRK1A | |
| SCHEMBL12343680 | 0.68 | MAPK1 (0.52) | LRRK2DYRK1APRKD3MAP4K4CLK2 | |
| SCHEMBL28520194 | 0.68 | CHUK (0.65) | GRM5LRRK2DYRK1APRKD3MAP4K4 | |
| Hydrochloric Acid SCHEMBL11469991 | 0.67 | ADORA1 (0.48) | NPC1ALDH1A1TP53LOXRAB9A | |
| SCHEMBL20162906 | 0.67 | LRRK2 (0.45) | GRM5LRRK2DYRK1APRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838533-B2 | Azaindole inhibitors of MTP and ApoB | MERCK PATENT GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | APOB, MTPN, HDLBP | NPC1 46/4885ALDH1A1 3630/4885TP53 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.