Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL514236 | 0.83 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL23986463 | 0.83 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL2094070 | 0.83 | NOTUM (0.62) | RAB9ANPC1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL4089372 | 0.82 | PPARG (0.49) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL4106551 | 0.82 | NOTUM (0.66) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL1545210 | 0.82 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL12449556 | 0.82 | CCR6 (0.53) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL12694 | 0.79 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL1544696 | 0.79 | LMNA (0.46) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR | |
| SCHEMBL1544933 | 0.76 | CYP3A4 (0.44) | RAB9ANPC1SMN1; SMN2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |