Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | HTT | P42858 | 2/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | TNKS | O95271 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | SULT2A1 | Q06520 | 1/20 | 0.67 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.67 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11919901 | 0.91 | TP53 (1.00) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL13046998 | 0.91 | NPSR1 (0.90) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL11919909 | 0.91 | TP53 (0.84) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL11919903 | 0.88 | TP53 (1.00) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL13048272 | 0.83 | TSHR (0.83) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL13046997 | 0.82 | NPSR1 (0.74) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL11919942 | 0.82 | LMNA (0.78) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL11919898 | 0.80 | TNKS2 (1.00) | TP53LMNANPSR1TNKS2MAPT | |
| SCHEMBL11919979 | 0.80 | NPSR1 (0.87) | TP53LMNAHTTNPSR1TNKS2 | |
| SCHEMBL11919919 | 0.80 | ALDH1A1 (0.73) | TP53LMNAHTTNPSR1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139966-A1 | AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS | OSLO UNIVERSITY HOSPITAL HF (NO) | 2010-12-09 | — | — | WO | disclosed |