Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.57 |
| ▸ | GSK3B | P49841 | 6/20 | 0.57 |
| ▸ | NFATC1 | O95644 | 5/20 | 0.57 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13051144 | 0.86 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL13051145 | 0.84 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL13051149 | 0.83 | DYRK1A (0.56) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL3657990 | 0.81 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1MAP3K14DYRK1B | |
| SCHEMBL13051147 | 0.81 | DYRK1A (0.60) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL13051138 | 0.80 | DYRK1A (0.65) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL3378612 | 0.79 | TGFBR1 (0.52) | DYRK1AGSK3BNFATC1TGFBR1CYP1A2 | |
| SCHEMBL13051143 | 0.79 | DYRK1A (0.57) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL13051111 | 0.78 | DYRK1A (0.62) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 | |
| SCHEMBL13051139 | 0.77 | DYRK1A (0.64) | DYRK1AGSK3BNFATC1MAP3K14TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | DYRK1A 2428/4885GSK3B 1642/4885NFATC1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.