Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | RAD52 | P43351 | 2/20 | 0.63 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609332 | 0.94 | RAD52 (0.70) | ATMMAPTKDM4ETSHRALOX12 | |
| SCHEMBL609122 | 0.94 | RAD52 (0.70) | ATMMAPTKDM4ETSHRALOX12 | |
| SCHEMBL5024481 | 0.94 | RAD52 (0.70) | ATMMAPTKDM4ETSHRALOX12 | |
| SCHEMBL6819364 | 0.91 | RAD52 (0.76) | ATMMAPTKDM4ERAD52NLRP1 | |
| SCHEMBL16211042 | 0.91 | RAD52 (0.76) | ATMMAPTKDM4ETSHRALOX12 | |
| SCHEMBL6816191 | 0.91 | RAD52 (0.76) | ATMMAPTKDM4ERAD52NLRP1 | |
| SCHEMBL1306615 | 0.87 | MEN1 (0.70) | ATMMAPTKDM4ERAD52NLRP1 | |
| SCHEMBL610230 | 0.87 | MEN1 (0.73) | ATMMAPTKDM4ERAD52LMNA | |
| SCHEMBL6823233 | 0.84 | RAD52 (0.86) | MAPTKDM4ERAD52NLRP1LMNA | |
| SCHEMBL607619 | 0.84 | LMNA (0.81) | ATMMAPTKDM4ERAD52NLRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |
| US-8053436-B1 | 9-(piperazinylalkyl) carbazoles as bax-modulators | MERCK SERONO SA (CH) | 2011-11-08 | — | — | US | disclosed |