Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 3/20 | 0.76 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816191 | 1.00 | RAD52 (0.76) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL1306615 | 0.94 | MEN1 (0.70) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL6823233 | 0.93 | RAD52 (0.86) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL607619 | 0.93 | LMNA (0.81) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL1305266 | 0.91 | ATM (0.73) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL608269 | 0.89 | LMNA (0.67) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL608502 | 0.88 | LMNA (0.74) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL608488 | 0.88 | RAD52 (0.66) | RAD52NLRP1LMNAMAPTHTT | |
| SCHEMBL6815269 | 0.87 | POLB (0.84) | RAD52LMNAMAPTHTTALDH1A1 | |
| SCHEMBL609714 | 0.85 | RAD52 (0.74) | RAD52NLRP1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004020422-A1 | 1, 4- SUBSTITUTED PIPERIDINE DERIVATIVES AND USE THEREOF AS BASE-INHIBITORS IN TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | claimed |
| WO-2004020422-A1 | 1, 4- SUBSTITUTED PIPERIDINE DERIVATIVES AND USE THEREOF AS BASE-INHIBITORS IN TREATMENT OF ALZHEIMER'S DISEASE | DE NOVO PHARMACEUTICALS LIMITED (GB) | 2004-03-11 | — | — | WO | disclosed |