Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15693967 | 0.77 | ALDH1A1 (0.59) | CYP3A4CYP2C9CYP2C19RAB9AMAPT | |
| SCHEMBL13081239 | 0.77 | CYP3A4 (0.66) | CYP3A4CYP2C9CYP2C19RAB9AMAPT | |
| SCHEMBL15693964 | 0.76 | ALDH1A1 (0.55) | CYP3A4CYP2C9CYP2C19RAB9AMAPT | |
| SCHEMBL13053300 | 0.75 | GLA (0.43) | SMN1; SMN2BACE1 | |
| SCHEMBL15922820 | 0.72 | RAB9A (0.59) | RAB9AMAPTSMN1; SMN2TSHRL3MBTL1 | |
| SCHEMBL20718709 | 0.72 | ESR1 (0.42) | ALDH1A1 | |
| SCHEMBL7383650 | 0.72 | TSHR (0.69) | CYP3A4RAB9AMAPTSMN1; SMN2TSHR | |
| SCHEMBL15923755 | 0.72 | RAB9A (0.62) | CYP3A4CYP2C9CYP2C19RAB9AMAPT | |
| SCHEMBL2733035 | 0.72 | MAPT (0.61) | CYP2C19RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL8777033 | 0.71 | CYP3A4 (0.71) | CYP3A4CYP2C9CYP2C19RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233976-B2 | Berbamine derivatives | CITY OF HOPE (US) | 2016-01-12 | — | — | US | disclosed |
| US-20140155423-A1 | BERBAMINE DERIVATIVES | CITY OF HOPE (US) | 2014-06-05 | — | — | US | disclosed |
| US-8722698-B2 | Berbamine derivatives | CITY OF HOPE (US) | 2014-05-13 | — | — | US | disclosed |
| US-20100298369-A1 | BERBAMINE DERIVATIVES | CITY OF HOPE | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298369-A1 | BERBAMINE DERIVATIVES | BAK1, MCL1, BAD | CYP3A4 861/4885CYP2C9 1675/4885CYP2C19 2169/4885 |
| US-20140155423-A1 | BERBAMINE DERIVATIVES | BAK1, MCL1, BAD | CYP3A4 861/4885CYP2C9 1675/4885CYP2C19 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.