Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12998009 | 0.69 | NOTUM (0.49) | ATMSMN1; SMN2DDB1CRBNMEN1 | |
| SCHEMBL13054008 | 0.68 | PLA2G1B (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1127259 | 0.65 | ATM (1.00) | ATMSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL13575371 | 0.65 | SMN1; SMN2 (0.56) | ATMSMN1; SMN2DDB1CRBNMEN1 | |
| SCHEMBL3550482 | 0.65 | NOTUM (0.53) | ATMSMN1; SMN2DDB1CRBNMEN1 | |
| SCHEMBL25294091 | 0.64 | SMN1; SMN2 (0.47) | ATMSMN1; SMN2MEN1KMT2ANOTUM | |
| SCHEMBL28852170 | 0.64 | ATM (0.43) | ATMSMN1; SMN2DDB1CRBNMEN1 | |
| SCHEMBL15803829 | 0.64 | SMN1; SMN2 (0.50) | ATMSMN1; SMN2DDB1CRBNMEN1 | |
| SCHEMBL7768522 | 0.64 | SMN1; SMN2 (1.00) | ATMSMN1; SMN2DDB1CRBNMEN1 | |
| SCHEMBL12998008 | 0.63 | SMN1; SMN2 (0.41) | ATMSMN1; SMN2DDB1CRBNMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305200-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305200-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, ATP2A1 | ATM 3512/4885SMN1; SMN2 732/4885DDB1 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.