Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.85 |
| ▸ | HTT | P42858 | 1/20 | 0.85 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.69 |
| ▸ | PRNP | P04156 | 2/20 | 0.69 |
| ▸ | PPARG | P37231 | 2/20 | 0.69 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.69 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15486910 | 0.87 | ALDH1A1 (0.71) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL8349971 | 0.83 | ALDH1A1 (0.66) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL11091591 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL31271707 | 0.82 | ALDH1A1 (0.64) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL20534577 | 0.81 | ALDH1A1 (0.62) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL31442647 | 0.81 | ALDH1A1 (0.76) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL2725020 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL15487502 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL3970605 | 0.79 | PRNP (0.79) | ALDH1A1HTTRXFP1PRNPPPARG | |
| SCHEMBL13136430 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HTTRXFP1PRNPPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048896-B2 | Inhibit nonenzymatic formation of advanced glycation end-products (AGE) using e.g. aminoguanidine, OPB-9195 [(+/-)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-yla cetanilide], pyridoxamine, antioxidants, alagebrium, antihypertensives, angiotensin-converting enzyme inhibitors | Cell Viable Corporation (US) | 2011-11-01 | — | — | US | claimed |
| EP-1165064-B1 | NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGE'S) | HOPE CITY (US) | 2004-02-25 | — | — | EP | claimed |
| US-6337350-B1 | CROSSLINKING INHIBITION OF PROTEINS | CITY OF HOPE | 2002-01-08 | — | — | US | claimed |
| EP-1165064-A2 | NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGE'S) | City of Hope (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059875-A2 | NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGE'S) | CITY OF HOPE (US) | 2000-10-12 | — | — | WO | claimed |
| US-8053449-B2 | Method for inhibiting AGE complex formation | Cell Viable Corporation (US) | 2011-11-08 | — | — | US | disclosed |
| US-8048896-B2 | Inhibit nonenzymatic formation of advanced glycation end-products (AGE) using e.g. aminoguanidine, OPB-9195 [(+/-)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-yla cetanilide], pyridoxamine, antioxidants, alagebrium, antihypertensives, angiotensin-converting enzyme inhibitors | Cell Viable Corporation (US) | 2011-11-01 | — | — | US | disclosed |
| US-20080076804-A1 | METHODS FOR INHIBITING AND BREAKING AGE COMPLEX FORMATION | Cell Viable Corporation | 2008-03-27 | — | — | US | disclosed |
| US-20070099966-A1 | Device and Method for Inhibiting AGE Complex Formation | Cell Viable Corporation | 2007-05-03 | — | — | US | disclosed |
| WO-2007044309-A2 | DEVICE AND METHOD FOR INHIBITING AGE COMPLEX FORMATION | VASIX CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| EP-1165064-B1 | NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGE'S) | HOPE CITY (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6337350-B1 | CROSSLINKING INHIBITION OF PROTEINS | CITY OF HOPE | 2002-01-08 | — | — | US | disclosed |
| US-4440768-A | ANTIPSYCHOTIC, ANALGESIC AND ANTIDEPRESSANT AGENTS | ICI AMERICAS INC. (US) | 1984-04-03 | — | — | US | disclosed |
| US-4350814-A | ANTIPSYCHOTIC, ANALGESIC, ANTIDEPRESSANT | ICI AMERICAS INC. (US) | 1982-09-21 | — | — | US | disclosed |
| EP-0029286-A1 | Pyrrolo(3,4-c)quinoline derivatives, processes therefor, and pharmaceutical compositions | ICI AMERICAS INC. (US) | 1981-05-27 | — | — | EP | disclosed |
| US-4268513-A | ANALGESICS, ANTIDEPRESSANTS, ANTIPSYCHOTICS | ICI AMERICAS INC. (US) | 1981-05-19 | — | — | US | disclosed |