Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14194677 | 0.89 | CSF1R (0.43) | CSF1RKITNPC1RAB9AHDAC4 | |
| SCHEMBL12647025 | 0.89 | GPR55 (0.49) | CSF1RKITGPR55CXCR4HDAC1 | |
| SCHEMBL13056490 | 0.88 | FABP1 (0.45) | CSF1RKITNPC1RAB9AGPR55 | |
| SCHEMBL12646870 | 0.86 | CLK4 (0.42) | CSF1RKITNPC1RAB9AGPR55 | |
| SCHEMBL12646947 | 0.86 | KDM4E (0.48) | CSF1RKITNPC1RAB9AP2RX7 | |
| SCHEMBL12304343 | 0.85 | CSF1R (0.43) | CSF1RKITNPC1RAB9AACHE | |
| SCHEMBL12927195 | 0.82 | GPR55 (0.35) | CSF1RKITNPC1RAB9AGPR55 | |
| SCHEMBL12926932 | 0.82 | STIM1 (0.39) | CSF1RKITNPC1RAB9AP2RX7 | |
| SCHEMBL14194746 | 0.82 | KDM4E (0.36) | CSF1RKITNPC1RAB9AP2RX7 | |
| SCHEMBL12927443 | 0.81 | CSF1R (0.46) | CSF1RKITNPC1RAB9AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846941-B2 | Compounds modulating c-kit and c-fms activity and uses therefor | PLEXXIKON, INC. (US) | 2010-12-07 | — | — | US | disclosed |