Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | GPR39 | O43194 | 2/20 | 0.36 |
| ▸ | FABP1 | P07148 | 1/20 | 0.35 |
| ▸ | FABP6 | P51161 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13056490 | 0.91 | FABP1 (0.45) | KDM4EALDH1A1NPC1GAARAB9A | |
| SCHEMBL12646870 | 0.89 | CLK4 (0.42) | KDM4EALDH1A1NPC1GAARAB9A | |
| SCHEMBL12647025 | 0.89 | GPR55 (0.49) | KDM4EALDH1A1MAPTCXCR4CSF1R | |
| SCHEMBL12927279 | 0.88 | P2RX7 (0.40) | KDM4EMAPTGAAPOLBP2RX7 | |
| SCHEMBL13056388 | 0.86 | CSF1R (0.52) | NPC1RAB9ACXCR4P2RX7CSF1R | |
| SCHEMBL12926539 | 0.83 | SMN1; SMN2 (0.45) | ALDH1A1NPC1RAB9AMEN1LMNA | |
| SCHEMBL14194677 | 0.83 | CSF1R (0.43) | NPC1RAB9ACSF1RKIT | |
| SCHEMBL12927195 | 0.83 | GPR55 (0.35) | NPC1RAB9ADYRK1ACXCR4CSF1R | |
| SCHEMBL12926932 | 0.83 | STIM1 (0.39) | NPC1RAB9ACXCR4P2RX7CSF1R | |
| SCHEMBL13976937 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1CLK4DYRK1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947708-B2 | Compounds modulating C-kit activity | PLEXXIKON, INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090105297-A1 | Compounds Modulating C-Kit Activity | PLEXXIKON INC | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105297-A1 | Compounds Modulating C-Kit Activity | KIT, CDC7, CDK7 | KDM4E 399/4885ALDH1A1 2624/4885MAPT 4263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.