Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 13/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | ALB | P02768 | 2/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396195 | 0.92 | SMN1; SMN2 (0.61) | FOLH1SMN1; SMN2SIRT1ALBSIRT5 | |
| SCHEMBL23983058 | 0.86 | FOLH1 (0.48) | FOLH1SMN1; SMN2SIRT1ALBSIRT5 | |
| SCHEMBL3952346 | 0.82 | MEN1 (0.51) | FOLH1SMN1; SMN2SIRT1SIRT5SIRT2 | |
| SCHEMBL3952344 | 0.82 | MEN1 (0.51) | FOLH1SMN1; SMN2SIRT1SIRT5SIRT2 | |
| SCHEMBL1681305 | 0.81 | FOLH1 (0.58) | FOLH1SMN1; SMN2SIRT1 | |
| SCHEMBL1681301 | 0.81 | FOLH1 (0.58) | FOLH1SMN1; SMN2SIRT1 | |
| SCHEMBL16393150 | 0.79 | FOLH1 (0.71) | FOLH1SMN1; SMN2SIRT1ALBSIRT5 | |
| SCHEMBL1200060 | 0.79 | FOLH1 (0.71) | FOLH1SMN1; SMN2SIRT1ALBSIRT5 | |
| SCHEMBL2735591 | 0.79 | FOLH1 (0.71) | FOLH1SMN1; SMN2SIRT1ALBSIRT5 | |
| SCHEMBL15423761 | 0.77 | GSR (0.50) | NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354477-B2 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly(ethylene glycol) and related polymers for modification of surfaces and molecules | NEKTAR THERAPEUTICS (US) | 2013-01-15 | — | — | US | disclosed |
| US-20100298496-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | NEKTAR THERAPEUTICS (US) | 2010-11-25 | — | — | US | disclosed |
| US-7786221-B2 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules | NEKTAR THERAPEUTICS (US) | 2010-08-31 | — | — | US | disclosed |
| US-20090054590-A1 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298496-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | MPG, PARG, PCNA | FOLH1 2661/4885SMN1; SMN2 4461/4885SIRT1 4210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.