Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | FOLH1 | Q04609 | 9/20 | 0.57 |
| ▸ | ALB | P02768 | 2/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GNPAT | O15228 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13057107 | 0.92 | FOLH1 (0.55) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| SCHEMBL1200060 | 0.88 | FOLH1 (0.71) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| SCHEMBL16393150 | 0.88 | FOLH1 (0.71) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| SCHEMBL2735591 | 0.88 | FOLH1 (0.71) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| SCHEMBL23983058 | 0.85 | FOLH1 (0.48) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| Bisorcic SCHEMBL2109664 | 0.82 | FOLH1 (0.64) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| Bisorcic SCHEMBL2109666 | 0.82 | FOLH1 (0.64) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| Bisorcic SCHEMBL16238411 | 0.82 | FOLH1 (0.64) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| SCHEMBL14942518 | 0.82 | FOLH1 (0.64) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 | |
| SCHEMBL2735587 | 0.82 | FOLH1 (0.56) | SMN1; SMN2FOLH1ALBSIRT5SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287653-A1 | METHOD FOR PRODUCING INHIBITORS AND INHIBITORS FORMED THEREFROM | THE UNIVERSITY OF AKRON (US) | 2008-11-20 | — | — | US | disclosed |