Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | MC4R | P32245 | 1/20 | 0.57 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MITF | O75030 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11004686 | 0.88 | ALDH1A1 (0.69) | ALDH1A1LMNACHRM2ADRA2BDRD3 | |
| Lanperisone SCHEMBL5819917 | 0.88 | CHRM2 (0.68) | ALDH1A1LMNAMC4RCHRM2ADRA2B | |
| Lanperisone SCHEMBL570832 | 0.88 | CHRM2 (0.68) | ALDH1A1LMNAMC4RCHRM2ADRA2B | |
| Hydrochloric Acid SCHEMBL11076147 | 0.87 | ALDH1A1 (0.71) | ALDH1A1LMNACHRM2ADRA2BDRD3 | |
| Lanperisone SCHEMBL5819985 | 0.86 | ALDH1A1 (0.68) | ALDH1A1LMNAMC4RCHRM2ADRA2B | |
| Lanperisone SCHEMBL1987393 | 0.86 | ALDH1A1 (0.68) | ALDH1A1LMNAMC4RCHRM2ADRA2B | |
| SCHEMBL9720545 | 0.86 | CHRM2 (0.70) | ALDH1A1LMNAMC4RCHRM2ADRA2B | |
| SCHEMBL14384871 | 0.85 | ALDH1A1 (0.72) | ALDH1A1LMNAMC4RCD274CHRM2 | |
| SCHEMBL10850475 | 0.83 | ALDH1A1 (0.74) | ALDH1A1LMNACHRM2ADRA2BDRD3 | |
| SCHEMBL11946057 | 0.82 | ALDH1A1 (0.72) | ALDH1A1LMNAMC4RCHRM2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298329-A1 | TOLPERISONE AND TOLPERISONE-LIKE DRUGS FOR THE TREATMENT OF K-RAS ASSOCIATED CANCERS | MASSACHUSETTE INSTITUTE OF TECHNOLOGY (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298329-A1 | TOLPERISONE AND TOLPERISONE-LIKE DRUGS FOR THE TREATMENT OF K-RAS ASSOCIATED CANCERS | MASSACHUSETTE INSTITUTE OF TECHNOLOGY (US) | 2010-11-25 | — | — | US | disclosed |
| WO-2009038771-A2 | TOLPERISONE AND TOLPERISONE-LIKE DRUGS FOR THE TREATMENT OF K-RAS ASSOCIATED CANCERS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298329-A1 | TOLPERISONE AND TOLPERISONE-LIKE DRUGS FOR THE TREATMENT OF K-RAS ASSOCIATED CANCERS | NRAS, KRAS, RASGRP1 | ALDH1A1 675/4885LMNA 4731/4885MC4R 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.