Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 18/20 | 0.69 |
| ▸ | CHRM2 known ✓ | P08172 | 13/20 | 0.69 |
| ▸ | CHRM1 known ✓ | P11229 | 9/20 | 0.69 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.69 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.69 |
| ▸ | HRH1 | P35367 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL131394 | 1.00 | CHRM3 (0.69) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL7145497 | 0.99 | CHRM3 (0.68) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13716305 | 0.99 | CHRM3 (0.68) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL13716300 | 0.99 | CHRM3 (0.68) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL7145504 | 0.99 | CHRM3 (0.68) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL170999 | 0.99 | CHRM3 (0.68) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL7151353 | 0.94 | CHRM3 (0.61) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL7140049 | 0.93 | CHRM3 (0.60) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL7147345 | 0.93 | CHRM3 (0.60) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL7140053 | 0.93 | CHRM3 (0.60) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572641-B1 | Method for production of theR,R (or S,S) configuration of glycopyrronium stereoisomers | MEDA PHARMA GMBH & CO KG (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-7569598-B2 | Process for the preparation of the R,R (or S,S) configured glycopyrronium stereoisomer | MEDA PHARMA GMBH & CO. KG (DE) | 2009-08-04 | — | — | US | disclosed |
| US-20060167275-A1 | Process for the preparation of the r,r (or s,s) configured glycopyrronium stereoisomer | PHARMACON FORSCHUNG UND BERATUNG G.M.B.H. (AT) | 2006-07-27 | — | — | US | disclosed |
| EP-1572641-A1 | METHOD FOR PRODUCTION OF THE R,R (OR S,S) CONFIGURATION OF GLYCOPYRRONIUM STEREOISOMERS | PharmaCon Forschung und Beratung GmbH (AT) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004054971-A1 | METHOD FOR PRODUCTION OF THE R,R (OR S,S) CONFIGURATION OF GLYCOPYRRONIUM STEREOISOMERS | PHARMACON FORSCHUNG UND BERATUNG G.M.B.H. (AT) | 2004-07-01 | — | — | WO | disclosed |
| EP-1369414-A1 | Enantiomerically pure Arylcycloalkyl hydroxycarboxylic esters, processes for their preparation and their use as modulators of muscarinic receptors | Noe, Christian R. (AT) | 2003-12-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167275-A1 | Process for the preparation of the r,r (or s,s) configured glycopyrronium stereoisomer | GYPA, TSHR, TRHR | CHRM3 151/4885CHRM2 426/4885CHRM1 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.